Proton pump inhibitors are a class of novel drugs that are the mostpotent acid suppressors on the ma

Proton pump inhibitors are a class of novel drugs that are the mostpotent acid suppressors on the market today.  Since omeprazole’s introduction in 1990, they have been clinically proven to be better than H2RAs.  Over the past decade their use has been scrutinized because of several harmful disease associations. -C. difficile infection: FDA’s analysis of over 28 studies revealed that patients taking PPIs were at a 1.4-2.75 times greater risk of developing an infection -Fractures: FDA reviewed several studies and have concluded that PPIs in high doses, multiple daily doses, and/or continued therapy for longer than a year increase a person’s risk of osteoporosis related fracture -Magnesium: PPIs may decrease magnesium level, which can lead to muscle spasms, arrhythmias, seizures, and fatigue.  This typically occurs after long-term administration of PPIs, usually longer than a year.  Treatment may require magnesium replacement and PPI discontinuation -Dementia: Although several theories exist to possibly explain the mechanism, the association needs to be validated in large cohorts and tested in case-control studies. For now, it is probably safe to say a causal link is plausible. -H. Pylori infection causes gastritis, PUD, gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma and the association between the presence of H. pylori and NSAIDs and an increased incidence of PUD is well documented.How would you handle a patient who wants to begin long-term PPI use?What would your discussion with them entail?In what patients or disease states would you not recommend PPI use?What if H. Pylori is found to be present? This leaves the provider to make a professional decision. What would you recommend if a patient is taking esomeprazole and clopidrogel together?   Responses must be a minimum of 150 words, scholarly written, APA formatted, and referenced. 2 references are required (Author, Year) format. Health Science Science Nursing NSG 533 Share QuestionEmailCopy link Comments (0)

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